Skincare Skills

by Lydia

Skincare blogger

May 23, 2022

Is Salicylic Acid Soluble in Water?

Is salicylic acid soluble in water? Solubility is a molecule property that determines whether it is miscible with a solvent. In this case, H2O is the solvent. But what about the polar groups of salicylic acid? COOH and OH interact well with water, while the phenyl ring has no interactions with H2O, but it does have strong interactions with other salicylic acid molecules. Solubility depends on the balance of COOH/OH interactions with H2O and C6H4 with other salicylic acid molecules. Iodine does not dissolve in water, but it reacts with it to form hypoiodous and hydroiodic acids, respectively.

Acetylsalicylic acid

Using an aqueous-cosolvent system (ACM), pharmaceutical companies can increase the solubility of a poorly water-soluble drug, such as acetylsalicylic acid, resulting in a liquid dosage form. Among the most common cosolvents used by pharmaceutical companies, ethanol is one of the most effective. Therefore, ACM can predict the solubility trend of acetylsalicylic acid in various ethanol fractions.

In a published research article, we present a general solvency model based on the Jouyban-Acree equations to predict the solubility of acetylsalicylic acid in ethanol and water. The Jouyban-Acree model requires only one datum for each temperature. The MRD% of acetylsalicylic acid in ethanol + water is 66.4%.

In addition to the saturation condition, the solubility of acetylsalicylic acid is also affected by temperature. Therefore, increasing the solubility of acetylsalicylic acid will result in a higher aqueous-water ratio and vice versa. This is why aqueous-water mixtures are more stable and reliable than other solutions.

Salicylic acid

Insoluble in water, salicylic acid is a white crystalline compound used to produce aspirin and other drugs. It is also found in nature, occurring in small amounts in plants. This compound is extracted from the bark of the willow tree and was recognized by the ancients for its medicinal properties. Today, salicylic acid is found in various products, including aspirin and skincare products. It is also used as an antiseptic in toothpaste and food preservatives. It has a pleasant wintergreen aroma and is also used in perfume preparations.

The solubility of salicylic acid should be viewed as a balance between interactions of the entire molecule and its solvent. For example, COOH and OH are the polar groups in salicylic acid, and they have a good interaction with H2O. On the other hand, the phenyl ring has no interaction with H2O, but it does have a very strong interaction with other salicylic acid molecules. Thus, the solubility of salicylic acid will depend on the balance between COOH/OH interactions with H2O and C6H4 interactions with other salicylic acid molecules.

The pure form of salicylic acid crystallizes from hot water in the form of white needles. It melts at temperatures around 159 degrees Celsius and sublimes without decomposition at 155 degrees C. However, salicylic acid will decompose into phenol and carbon dioxide when heated to a higher temperature. The resulting product is a white powder that can be applied to the skin.

Methyl salicylate

Methyl salicylate is a chemical compound that is soluble in water. As a result, it is highly toxic when taken internally, and one teaspoon contains seven grams of salicylate, equivalent to 23 300-mg aspirin tablets. While the lowest lethal dose for an adult human is 101 mg per kilogram of body weight, the drug has been fatal in small children. For example, a seventeen-year-old cross-country runner was killed after swallowing four ml of the drug.

Methyl salicylate is slightly soluble in water but also in most organic solvents. The vapor pressure of methyl salicylate is 0.0343 mm Hg at 25 degrees Celsius. It also undergoes hydrolysis in the presence of an aqueous base, yielding salicylic acid and methanol. However, if consumed in large quantities, it can cause serious health problems, including kidney and stomach problems.

Methyl salicylate is a common chemical found in many products, including fragrances and liniments. It is produced by plants such as wintergreen and is naturally present in many foods. The odor is characteristic of wintergreen, and its uses are wide. However, its toxicity is a reason for its limited use as an antiseptic. Solubility in water makes it an ideal solvent for cosmetics and pharmaceutical products.

Sodium salicylate

Sodium salicylate is a white crystalline powder with needle-shaped crystals. It is soluble in water, alcohol, chloroform benzene, and acetone and slightly soluble in carbon dioxide. It is produced commercially as sodium salicylate by treating sodium phenolate with carbon dioxide. The final product has a pH of approximately 9.0 and is soluble in water.

The compound sodium salicylate is soluble in water and is used in medicines as an analgesic and antipyretic. However, it triggers Reye's syndrome in children. Sodium salicylate is incompatible with strong acids and oxidizing agents. It is a phosphor for electron detection and maybe a substitute for aspirin. This substance may also be used as a phosphor to detect electrons and vacuum ultraviolet radiation.

Sodium salicylate is a salt of salicylic acid. The reaction between sodium salicylate and sodium bicarbonate produces a soluble salt of salicylate. Sodium salicylate darkens in water when compared to its acidic counterpart. Sodium salicylate inhibits COX-2 activity in A549 cells after 30-min exposure. This is true whether the cells are exposed to sodium salicylate alone or in the presence of an exogenous substrate such as arachidonic acid.

Sodium phosphate

The solubility of sodium phosphate and salicylic acid in water is a significant characteristic of these compounds. Both compounds are highly soluble in water and can be dissolved in various biological fluids and foods. Moreover, their solubility in water has a clear linear relationship with the surface area of the solution. In contrast, salicylic acid and its derivatives are incompatible with iron salts and oxidizing substances.

In the case of salicylic acid, this relationship is not so clear since the pH values of both compounds are negative. However, these compounds are soluble in water at pH levels between 273 and 373. In addition, the ionization level of the buffer also affects the number of drug molecules released. Thus, the solubility-pore saturation interplay may explain the difference in the transport of salicylic acid in water.

Sodium fl-sulfoethylacetylsalicylate is a monobasic compound with a ph level of 5.5. The sodium salt of salicylic acid is soluble in water and has a ph value of between 5 and 6.


Salicylic acid is a white powder, crystalline, and odorless chemical derivative of aspirin. It is very soluble in water, alcohol, and borax and is insoluble in iron salts and oxidizing materials. It is also available as a preservative in food stores. It is soluble in water and borax but not in acetone.

The chemical formula of salicylic acid is H3BO3. It can dissolve in five to ten percent of water in a soap solution. Therefore, it can also be used as a multipurpose cleaner. Borax is soluble in water, is nonflammable, and has no reactivity. Therefore, it dissolves best in water. However, in large doses, borax is toxic. Therefore, it is recommended that you use borax only with a small amount of water.

It is safe to use salicylic acid as a topical solution for various skin conditions. For example, it is used for eczema, psoriasis, acne, and dandruff. However, only a small proportion of salicylic acid is safe in the bathroom. Moreover, the concentration of salicylic acid in any product should not exceed 2%.


Generally speaking, aspirin is soluble in water. However, the substance decomposes quickly when dissolved in water. It forms alkali hydroxides and carbonates when dissolved in water. Both the inorganic salt and the calcium salt of aspirin are soluble in water. In its crystalline form, aspirin is not soluble in water, so a sample of aspirin should be prepared in a clean test tube. The IA will then run the sample on HPLC to get a chromatogram of the crude aspirin.

The synthesis of aspirin begins by treating salicylic acid with an excess of acetic anhydride. Then, a small amount of a strong acid is added as a catalyst to speed up the process. The result is an ester. Salicylic acid is a byproduct of the manufacturing process for aspirin. The chemical compound aspirin is considered a multibillion-dollar industry.

To manufacture aspirin, the ingredient Salicylic acid is extracted from the bark of the Willow tree. German chemist Johann Andreas Buchner first isolated this substance in 1828. French pharmacist Henri Leroux discovered the substance in greater quantities in 1829. In the 1880s, Italian chemist Raffaele Piria isolated salicin from the herb meadowsweet. Salicylic acid is also used in sunburn creams and enteric-coated pills.


What is the solubility of salicylic acid in water?

Salicylic acid is soluble in water—the solubility increases as the temperature increases.

How do you make salicylic acid more soluble in water?

There are a few ways to make salicylic acid more soluble in water. One way is to add a solvent like ethanol or acetone to the solution. Another way is to increase the temperature of the solution. Salicylic acid is more soluble in hot water than in cold water.

Can I mix salicylic acid with water?

Yes, you can mix salicylic acid with water. However, it's essential to note that salicylic acid is a powerful chemical and can cause skin irritation if not used correctly. Therefore, always test a small skin area before applying any new product to a large area.

Is salicylic acid-stable?

Salicylic acid is a relatively stable compound, but it can degrade over time in the presence of light or air.

Does water neutralize salicylic acid?

Water will not neutralize salicylic acid. Instead, water can increase the potency of salicylic acid, making it more effective in breaking down the keratin that makes up the top layer of skin.

What can you mix salicylic acid with?

Salicylic acid is a beta hydroxy acid that is used to treat acne. It can be mixed with other acne treatments, such as benzoyl peroxide or sulfur. It can also help reduce dryness when mixed with a moisturizer.

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About the author 


My name is Lydia Adams and I have been a skincare blogger in one way or another for many, many years.

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