Skin Care

Cetaphil Deep Hydration Serum: Proven to Restore Skin’s Appearance



by Lydia


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Many of us struggle with unique skin problems, such that we constantly find ourselves trying out different products to restore skin's appearance. Dry, sensitive skin is one such common condition, one that's proven equally challenging to find a long-lasting solution. If this sounds familiar to you, then there's good news: Cetaphil Deep Hydration 48-Hour Activation Serum is formulated to deeply replenish skin's hydration and also soothes skin sensitivity to give you back your former glow.

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A Brief History of Cetaphil

Cetaphil was founded in 1947 by a Texas pharmacist. The brand's first product was a cleansing lotion, which contained the same formula as today's Cetaphil Gentle Skin Cleanser. Over time, the brand broadened its product range, gradually gaining a solid reputation for simple, science-based products to help manage dry skin, sensitive skin as well as problematic acne-prone skin.

Cetaphil is often recommended by dermatologists and within healthcare settings, thanks to simple, effective ingredients that treat and manage a range of skin conditions. Today, this facial skincare brand is well-known globally for its range of moisturizers and cleansers to treat sensitive, acne-prone or compromised skin.

Does Cetaphil Really Work?

The short answer is yes. Cetaphil has a vast array of products and thousands of 5-star reviews, so it only follows that the brand is a skincare staple. Its simple, science-based formulations, with no frills, can form the foundation of a rewarding skin care routine. On top of the products' basic ingredients, their accessibility and affordability make the brand high-recommended, especially for people with skin sensitivity.

What's Cetaphil Deep Hydration 48 Hour Activation Serum?

Cetaphil Deep Hydration 48 Hour Activation Serum is a lightweight formula designed for soothing dry skin. It absorbs instantly to nourish and replenish the skin's hydration deeply for 48 hours and enhance the overall quality of sensitive skin. Given its gentle formula, it's equally a great fit for virtually any skin type and restores skin's radiant appearance. Furthermore, the serum has been tested by dermatologists and clinically proven to be effective.


Cetaphil Deep Hydration 48 Hour Activation Serum contains 30 ingredients. The notable ones include:

  • Hyaluronic acid
  • Sunflower seed oil
  • Glycerin
  • Shea oil
  • Vitamin E
  • Vitamin B5


The serum contains Cetaphil's HydroSensitiv™ Complex that contains soothing blue daisy to enhance dynamic hydration as well as soothe and enhance the quality of sensitive skin over time. It also has hyaluronic acid, antioxidant-rich vitamin E, vitamin B5 and sunflower seed oil to rehydrate and reinvigorate your skin's appearance. Furthermore, the serum is formulated to defend against five signs of skin sensitivity, such as dryness, roughness, tightness, irritation and a weakened skin barrier.

It's a layerable serum, so you can use it alone or under other products for an added boost to your skin's hydration.

In a nutshell, the Cetaphil Deep Hydration Activation serum is:

  • Ideal for dehydrated or dry skin.
  • Fragrance-free
  • Paraben-free
  • Hypoallergenic
  • Non-comedogenic, so it won't clog pores.

1. Texture/Feel

Since Cetaphil Deep Hydration Serum can be used in addition to, or instead of, a moisturizer. It has more moisturizer-like qualities compared to other face serums. When pumped into your hand, it mimics the look and feel of a light moisturizer and feels like one when applied. Nevertheless, it’s not as heavy as a moisturizer once it absorbs into your skin, meaning it’s quite manageable as a serum underneath a moisturizer.

In addition, it tends to leave behind a slightly tacky residue once it's absorbed, but it’s pretty comfortable to wear overall.

2. Application

Cetaphil Deep Hydration Serum is nearly as simple as it can be in terms of application. You simply apply a pump of the product on clean, dry skin after cleansing both in the morning and at night. Once the serum absorbs into your skin, you can also layer other skincare products on top of it.

It's quite easy to incorporate this serum into your daytime and nighttime skincare routines. Most users say it wears well underneath makeup and hardly impacts the feel of other skincare products on their faces.

3. Drying Time

The moisturizer-like qualities give the impression that Cetaphil Deep Hydration Serum might have a longer dry time. However, that definitely isn't the case. It takes about 15-20 seconds for most of the product to absorb into your face and neck. This then allows you to layer other skincare products on top.

4. Smell

Cetaphil Deep Hydration 48 Hour Activation Serum has a pretty clean odor. The smell is refreshing but not overpowering. As soon as you wear other products, the smell fades out. This means you keep your preferred fragrance, but it could be a bummer if you like how it smells and would prefer to retain the scent.

5. Immediate Results

Cetaphil Deep Hydration 48 Hour Activation Serum works really fast. You'll see noticeable changes even after just one use, especially if you have dehydrated skin. Your complexion will look more hydrated, and if you're suffering from irritation, you'll also see a genuine improvement in no time! It also soothes skin sensitivity instantly, leaving your skin feeling and looking fresh.

6. Long-Term Results

The longer you use this deep hydration serum, the more you'll love how your skin looks and feels. The instant hydration builds up over time, leaving your complexion looking more plump and glowing.

You'll also see a significant reduction in skin discoloration, especially with skin redness and irritation. In addition, Cetaphil Deep Hydration 48 Hour Activation Serum leaves you with a clearer complexion than before.

7. Value

Cetaphil Deep Hydration 4 Hour Activation Serum is definitely worth the money, without a doubt! It's not expensive for starters, but it goes ahead to deliver the results it promises. It's truly great bang for your buck.

8. Guarantee

Cetaphil sells its products online and in major drugstores. Therefore, if you need information on the return policy or any other guarantees, it would be best to check with the vendor before you make the purchase, as it varies with each retailer.


  • Ideal for dehydrated or dry skin
  • Formulated and clinically tested for sensitive skin
  • Effective yet gentle skin care, won't clog pores or irritate the skin
  • Has a gentle scent
  • Can be used alone as well as layered under face lotion or cream


  • Slight tacky reside post-application

How to Use

Cetaphil recommends using the Deep Hydration Activation Serum every night and morning after cleansing. Ideally, you should smooth it gently over your face and neck. More so, the serum can be used alone, but you can also layer it under Cetaphil Deep Hydration Healthy Glow Daily Cream if you want a deep boost to the skin's hydration.


1. Apply to Add a Boost to Your Skincare Routine

After cleansing, apply the serum to target your specific skin concerns. Apply the serum all over the face and neck if you want a hydration boost.

2. Apply a Moisturizer to Help Rehydrate, Renew and Repair Your Skin

Using a moisturizer after applying the serum helps to boost your skin's moisture. It also protects it from dryness all day so that your skin looks and feels refreshed throughout.

Where to Buy

Cetaphil skincare products are typically not sold on the company’s website. Instead, Cetaphil is more of a drugstore brand, so its products are available at most pharmacies and grocery stores across the globe. Therefore, you can buy Cetaphil Deep Hydration 48 Hour Activation Serum on third-party online retailers, like Amazon, eBay, Ulta, etc., or in physical retail locations throughout the country, such as Walmart, Target and Walgreens. Furthermore, the Cetaphil website has a store locator to help you find a location near you.

Frequently Asked Questions (FAQs) on Cetaphil

1. Is Cetaphil vegan?

No. While most Cetaphil products don't have formulas with animal products, some do, like the Cetaphil Cleansing bar. However, the Deep Hydration Activation Serum is completely vegan.

2. Is Cetaphil cruelty-free?

Cetaphil holds that none of their products are tested on animals. That being said, their products are sold globally, which opens up the possibility of testing on animals in markets where it is mandated by law.

3. Is Cetaphil really affordable?

Yes. Cetaphil prides itself as an affordable and accessible brand. Most of their products range between $5-$20.


Like other products on the brand's skincare line, the Cetaphil Deep Hydration 48 Hour Activation Serum is great for people looking to restore and replenish their skin's hydration. It's pretty easy to apply and include into your day and nighttime skincare routines. You'll genuinely see an improvement in hydration and reduced skin irritation even after one use. More so, the longer you use it, the more your skin looks and feels healthier; this gentle formula leaves you with a plump, glowing complexion. Add all of that to a pocket-friendly price tag, and this amazing serum is a total winner. 


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