Skin Care

Best Moisturizer for Accutane Treatment



by Lydia


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Anyone who has struggled with acne has heard their dermatologist mention Accutane at least in one of their visits, or many patients might have seen the word as one of the solutions for the skin condition. The products you use while on Accutane, whether using a gentle cleanser, body wash, lip balm or petroleum jelly, should not irritate the skin, even the extra sensitive skin. 

Still, instead, it should work to replenish the natural moisture that it might be losing. Read on to understand better about the best moisturizers for Accutane and their pros and cons. 

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What is Accutane?

Accutane is a widely used oral treatment for severe cystic acne, and it has been around for decades and is also known as isotretinoin. It works exceptionally well to prevent any scarring and treat severe cysts and nodules associated with acne, and it can also cause dryness to the face and body. Accutane works by minimizing the amount of sebum produced by your sebaceous glands, and this is a side effect that can make your skin super dry, and that's why you need a good moisturizer and apply it regularly.

We have compiled a list of the best moisturizers for Accutane treatment, and these are exceptionally great with people experiencing dry skin. They will keep the skin moisturized without interfering with the treatment. 

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Cetaphil Soothing Gel-Cream is one of the best moisturizers for compromised skin with flaky skin, cracks or soothing ingredients such as aloe vera and allantoin. It is suitable for offering relief and repairing the skin's natural barrier, and since it's non-comedogenic, hypoallergenic and fragrance-free, it can be used on sensitive skin.

Cetaphil Soothing Gel-Cream with Aloe is a fragrance-free cream that is absorbed quickly into the skin, and it offers long-lasting hydration while protecting your skin from environmental aggressors or dry air. Notably, it's important to note that it's a body cream and not a face cream, so it is not the best option if you are looking for a face cream.


  • Clinically proven and dermatologist tested to be gentle on sensitive skin
  • It soothes the skin while delivering a 24-hour hydration
  • Ultra-lightweight and does not clog pores
  • It protects the skin against any environmental stressors such as cold, sun or wind.
  • Paraben, fragrance-free and hypoallergenic


  • Felt sticky to some users

Neutrogena Hydro Boost Hyaluronic Acid Face Moisturizer is one of the best-selling products in the market, and it comes with a blue pot with a twist-up lid. It has a water-thin consistency meaning it is very runny, and the product usually absorbs fast into your skin. It leaves your facial skin with a matte finish, and this is because of hyaluronic acid. The water gel hydrates your skin and leaves the skin soft and supple, and you can use a pea-sized amount for the face and neck, and it will last a long time.

Neutrogena Hydro Boost Hyaluronic Acid Face Moisturizer has a fresh and clean fragrance, and the lotion is gentle on your skin and will leave it soft and supple. It makes a great all-in-one moisturizer that leaves your skin feeling soft and smooth, and since it's non-irritating, the product can be used on all skin types oil, dry, normal and combination skin. 


  • It is suitable for all skin types.
  • Lightweight, so it can be used before makeup application
  • The skin care product is suitable for Accutane users thanks to the oil-free gel formula that causes unwanted side effects, clogged pores or breakouts
  • It leaves your skin hydrated and smooth and also doesn't make your skin oil
  • The moisturizer contains hyaluronic acid serum, and this means it can improve the aging skin texture
  • Quenches the extra dry skin during any season


  • Sometimes it needs to be applied multiple times in a day as it is a lightweight product.
  • The fragrance may be too intense for some people
  • A heavy and bulky pot that is not hygienic

La Roche-Posay Toleriane Face Moisturizer was designed for people who get irritated skin from added parabens, fragrances and alcohols. Thanks to some of its ingredients, the moisturizer is intensely nourishing, such as shea butter, glycerin, squalane, and thermal spring water. It is suitable for use on all skin types, including dry skin, oily skin, and combination skin.

La Roche-Posay Toleriane is super lightweight, and it's the best choice if you are not looking for the rich, heavy creams on your skin. The moisturizer is packed in an airtight container that prevents contaminants from entering and is free of preservatives and oils. 


  • Lightweight
  • Suitable for sensitive and acne-prone skin
  • Non-oily finish
  • Oils and preservatives free
  • It comes in an airtight container that prevents contaminants from getting inside.


  • It clogs some Accutane users' pores

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CeraVe Moisturizing Cream is among the best skin care products in the current market. It should be in every household because it's rich in both moistures attracting hyaluronic acid and the skin's barrier strengthening ceramides. In addition, the Cerave cream is better than the lotion because it has a thicker consistency, which locks in the moisture; hence, it's the best moisturizer for Accutane.

CeraVe Moisturizing Cream checks all the requirements you may need to check when shopping for products to use with Accutane, including hypoallergenic, fragrance-free and super hydrating. The treament has the Seal of Acceptance from the National Eczema Association and can also be used with people with sensitive skin. In addition, it can be used anywhere, whether on the face or the body and gives you the best value for your money.


  • Great value for your money
  • Suitable for sensitive skin as its fragrance-free
  • Suitable for children and babies with eczema
  • It includes the essential ceramides, which help to retain water in your skin and also protect it.
  • Provides a protective barrier for your skin
  • Non-greasy formula


  • Breaks out on some skin types

EltaMD intense face and body moisturizer is an extremely emollient moisturizer that best works for dry and susceptible skin. The product is fragrance-free, paraben-free, and doesn't have preservatives, ensuring safe use with sensitive skin.

EltaMD intense face and body moisturizer are great since you only need to apply a pea-size amount to dampen the skin. You will need to pat the moisturizer for about two minutes after application, and it will leave your face feeling moisturized. However, this moisturizer has to be used sparingly because it is one of the skin care products that does not absorb well for some Accutane patients. 


  • Suitable for people with psoriasis, redness, eczema or roughness, which can be caused by medication
  • Fragrance-free
  • It was incredibly moisturizing, and it will form a protective layer
  • You need to pat off moisturizer gently, and it remains two minutes after applying


  • It must be used sparingly, and some Accutane patients don't absorb well.

What are Some Accutane Side Effects?

While Accutane may be super effective, it has some significant side effects that everyone should know before using the drug. For example, Accutane may cause some dry skin issues such as redness, peeling, flakiness, itchiness, and it makes a face more irritable, and all these symptoms are seen not only on the face but anywhere on the body. Sometimes, Accutane users may experience chapped lips, prone to sensitivity, especially from the sun.

Factors to Consider Before Purchasing the Best Moisturizer for Accutane

1. Skincare Regimen

The skin care regimen is a crucial factor to consider before you choose which moisturizer is the best for you because you need to know how the use of Accutane will fit into your regimen. Apart from treatment goals in choosing which moisturizers to use with Accutane, you need to figure out which other needs you have before deciding on the best moisturizer for Accutane.

Some Accutane users would like to improve their skin's pigment changes, and others prefer a rejuvenating effect. You should jot down a few notes and goals about what you are looking for, and this will help narrow down what you want to gain from a product.

2. Skin type

Knowing your skin type is an essential consideration before you choose any skincare product, but it is essential to know that it may change after you start treatment with Accutane. For example, if you have oily skin, it would be better to opt for a lightweight moisturizer and if you have dry skin, opt for a thicker and more soothing emollient.

Notably, if you have sensitive skin and easily break into a rash and start flushing after applying something topical, you may be part of this category. There can be other signs of sensitive skin, and they may include unwanted irritation or peeling skin, hives, wheels or urticaria or frequent dermatitis outbreaks.

In addition, ensure you pay attention to the signs and symptoms that you may experience. For example, if your skin stings or has a burning sensation after you apply a new topical product, you might need to discontinue the use. When you are aware of your skin type, it will help you get the proper skin care regimen and help you decide which moisturizer to use together with Accutane.

3. Treatment course with Accutane

Also, you need to evaluate how the moisturizer you opt for will fit in your medical treatment plan, and it's better to ask your board-certified dermatologist how they think you may use the moisturizer. Most Accutane treatment courses usually last for a few months, which is about six to eight months, and this can be a long time for most people.

These doses may range from low and may increase depending on an individual's progress and response to treatment. For people with rare and more chronic conditions, it can be challenging to manage dermatological issues and therefore, the doses are kept for more extended periods.

All the above factors should be considered because the longer and higher dosed treatment regimens with Accutane may need a long-term and more aggressive moisturizing regimen.

Frequently Asked Questions on the Best Moisturizer for Accutane

1. Is it OK to exfoliate while on Accutane?

Since Accutane makes your skin susceptible, you should avoid exfoliating as exfoliating only irritates the skin. This applies to both chemical exfoliants such as AHAs and BHA and physical exfoliants such as a damp towel or a scrub.

Some of these medications and over-the-counter products may result in your skin being more sensitive or peeling. This can be with prescriptions such as retinoid creams or products that contain benzoyl peroxide or retinol. In addition, exfoliating when using these products may cause extra dryness and even cause acne breakouts.

2. Can you use acne cream while on Accutane?

Since your skin is super sensitive and dry, try to avoid acne creams or any acne-fighting tropical products such as benzoyl peroxide, tea tree oil or salicylic acid. This will further irritate and eventually cause skin dryness, and you should be focusing on products that hydrate and healing products while you are on Accutane.

In addition to things you should avoid while on Accutane, you should also avoid Vitamin A supplements during your treatment and tobacco and alcohol. Notably, you can use a moisturizing cream, healing ointment, cleanser, hyaluronic acid, and SPF to ensure your skin is clean, hydrated, and protected during the treatment.

3. How do I keep my dry skin moisturized?

Some of the ways you can ensure your dry skin is moisturized are:

  • Use a moisturizer to offer a seal
  • Use lukewarm water and also limit the bath time
  • You should avoid the harsh and drying soaps
  • Using a humidifier

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